De La Salle University's Lady Spikers secured a hard-fought victory against the University of Santo Tomas in a five-set match, ending a losing streak against UST that dated back to Season 85. The game took place on March 29, 2025, with La Salle winning 15-25, 25-17, 24-26, 25-20, 16-14. Key players Angel Canino and Shevana Laput led the charge, with Canino being rushed to the hospital post-game due to dizziness after a collision. La Salle's next match is against Ateneo on April 2, 2025.